期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 140, 期 2, 页码 201-204出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1016/j.jphs.2019.05.007
关键词
Microautophagy; Chaperone-mediated autophagy; Rapamycin
资金
- Japan Society for the Promotion of Science KAKENHI [16K08276]
- Grants-in-Aid for Scientific Research [16K08276] Funding Source: KAKEN
Autophagy-lysosome proteolysis is classified into macroautophagy (MA), microautophagy (mA) and chaperone-mediated autophagy (CMA). In contrast to MA and CMA, mA have been mainly studied in yeast. In 2011, mammalian mA was identified as a pathway to deliver cytosolic proteins into multivesicular bodies. However, its molecular mechanism is quite different from yeast mA. Using a cell-based method to evaluate mA and CMA, we revealed that rapamycin, an activator of yeast mA, significantly activated mammalian mA. Although rapamycin activates MA, mA was also activated by rapamycin in MA-deficient cells. These findings suggest that rapamycin is a first-identified activator of mammalian mA. (C) 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据