期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 169, 期 -, 页码 133-141出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2019.03.006
关键词
Chromatography; High performance liquid chromatography; Biological samples; Vitamin k; Phylloquinone; Menaquinones
资金
- Fred & Pamela Buffett Cancer Center Support Grant from the National Cancer Institute [P30 CA036727]
- National Institutes of Health [P50CA127297]
- University of Nebraska Medical Center, College of Pharmacy fellowship award
Vitamin K is an essential nutrient in the body and involved in numerous physiological and pathophysiological functions. Both the lack and surplus of vitamin K can put human health at risk. Therefore, it becomes necessary to monitor vitamin K concentrations in different biomatrices through establishing sensitive and specific analytical methods. This review collectively describes an updated overview of the sample pretreatment methodologies and methods for quantitative determination of vitamin K that have been used in last two decades. High Performance Liquid Chromatography (HPLC) is commonly utilized as a standard for separation of vitamin K in combination with different detection including spectroscopic, spectrometric, fluorometric and mass spectroscopy. Recent progress in sample pretreatment technologies and quantitation methodologies have enhanced the ability to identify and quantitate vitamin K in biomatrices to further advance our understanding of the role of this vitamin in human health and disease. (C) 2019 Elsevier B.V. All rights reserved.
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