期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 10, 页码 6126-6133出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b00331
关键词
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资金
- National Key Research and Development Program of China [2016YFC0101200, 2018YFA0208800]
- National Natural Science Foundation of China [21572153]
- Key Research and Development Program of Social Development of Jiangsu Province [BE2018655]
- Key Program of Natural Science Foundation of Jiangsu Educational Committee [15KJA310004]
- Open Project Program of Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection [KJS1767]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Talent Culturing Plan for Leading Disciplines of University of Shandong Province
Lymphatic metastasis is an important prognostic indicator for cancer progression. It is therefore considerably meaningful to develop molecularly targeted imaging probes for noninvasive and accurate identification of metastatic lymph nodes (MLNs) at early stages of tumor metastasis. Herein, we report a novel matrix metalloproteinase-2 (MMP-2)-activatable probe constructed with a near-infrared dye (Cy5), a quencher (QSY21), and a tumor targeting peptide cRGD covalently linked through a radionuclide (I-125)-labeled peptide substrate for accurate detection of MLNs. Upon cleavage with activated MMP-2, the above probe emitted MMP-2 concentration-dependent near-infrared fluorescence, which allows sensitive and specific visualization of MLNs via both optical and single-photon emission computed tomography imaging techniques. We thus envision that this probe would serve as a useful tool for studying tumor-induced lymphangiogenesis.
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