期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 12, 页码 7747-7761出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b00644
关键词
-
资金
- DST-SERB, New Delhi, India [EMR/2016/003677/0C]
- CSIR
Efficient one-pot rhodium-catalyzed and base-mediated transannulation of N-sulfonyl-1,2,3-triazoles with a Michael acceptor-tethered indole derivative have been achieved for the synthesis of dihydro-beta-carboline derivatives. The present methodology involves an efficient rhodium-catalyzed insertion of azavinyl carbenes to C3-H bond of indole followed by base-mediated intramolecular aza-Michael reaction. The optimized conditions tolerate various functional groups and afford the diverse dihydro-beta-carbolines in good yield. The method was successfully extended to the synthesis of dihydroisoquinolines employing Michael acceptor-tethered aniline derivatives. The potential of the developed method was demonstrated through one-pot cascade synthesis of dihydro-beta-carbolines from alkyne and their conversion to vital carboline derivatives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据