期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 13, 页码 8411-8422出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b00208
关键词
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资金
- National Key R&D Program of China [2017YFD0201302-03]
- National Natural Science Foundation of China [21562012, 21762012]
- S&T Planning Project of Guizhou Province [[2017]1402, [2017]5788]
An efficient and chemoselective C(sp(2))-N bond cleavage of aromatic imidazo[1,2-a]pyridine molecules is developed. A broad scope of amide compounds such as alpha-ketoamides and N-(pyridin-2-yl)arylamides are afforded as the final products in up to quantitative yields. Diverse C-N bond cleavages are controlled by the oxidative species used in this transformation, with various amide products afforded in a chemoselective fashion. A preliminary study indicated that some alpha-ketoamides exhibit anti-Tobacco Mosaic Virus activity for potential use in plant protection.
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