期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 11, 页码 6576-6588出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b03056
关键词
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资金
- National Institute of General Medical Sciences [GM111835, GM120673]
Presented herein are two complementary approaches to the synthesis of the core N-glycan pentasaccharide. The first, a traditional manual approach in solution, makes use of the H-bond-mediated aglycone delivery method for the highly diastereoselective introduction of the beta-mannosidic linkage at room temperature. The synthesis of the core pentasaccharide was also accomplished using an high-performance liquid chromatography-assisted automated approach. The overall assembly was swift (8 h) and efficient (31%).
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