Direct C-H Multifluoroarylation of Ethers through Hydrogen Atom Transfer Using Photoredox Catalysis

A direct defluorinative multifluoroarylation of unactivated sp(3) C-H bonds through hydrogen atom transfer using photoredox catalysis has been developed. The C(sp(3))-C(sp(2)) couplings between C(sp(2))-F bonds and corresponding C(sp(3))-H bonds adjacent to heteroatoms proceeded smoothly to afford the desired products in moderate to good yields. Preliminary mechanistic investigations on this novel transformation revealed that the C-H cleavage process might be involved in the rate determining step.