期刊
JOURNAL OF ORAL PATHOLOGY & MEDICINE
卷 48, 期 8, 页码 696-704出版社
WILEY
DOI: 10.1111/jop.12888
关键词
invasive tumor front; oral squamous cell carcinoma; prognosis; TGF-beta; tumor center
Background Transforming growth factor-beta (TGF-beta) exerts its versatile function (oncogenic or tumor suppressive role) during the carcinogenesis in tumor microenvironment-dependent manner. Considering the tumor heterogeneity, spatial and temporal distribution of TGF-beta in oral squamous cell carcinoma (OSCC) remained to be elucidated. Methods Formalin-fixed, paraffin-embedded sections derived from 73 patients with OSCC were immunostained, revealing expression patterns of TGF-beta, both at the regions of tumor center (TC) and invasive tumor front (ITF). Results The TGF-beta levels on tumor cells, fibroblast-like cells (FLCs), and tumor-infiltrating lymphocytes (TILs) were comparable and showed to be cell-type-independent manner. Although TC regions harbored less positive staining of TGF-beta than ITF in tumor cells (TGF-beta(Tumor cell)) (89.0% vs 98.3%; P = 0.037), FLCs (TGF-beta(FLC)) (86.3% vs 96.6%; P = 0.043), and TILs (TGF-beta(TIL)) (83.6% vs 94.8%; P = 0.044), respectively, TGF-beta at TC regions, not at ITF, correlated to poor clinical outcomes. At TC regions, patients with high TGF-beta(Tumor cell) had high recurrence rate, and patients with high TGF-beta(TIL) showed inferior worst pattern of invasion. Of note, high TGF-beta(Tumor cell) at TC predicted shorter overall survival time, recurrence-free survival, and disease-free survival in patients with OSCC, whereas high TGF-beta(TIL) had no association with survival time. Cox regression analyses indicated that tumor cell-derived TGF-beta at TC was an independent risk factor for survival outcome in patients with OSCC. Conclusions Tumor cell-derived TGF-beta at TC regions, but not at ITF, could be a promising predictor for disease recurrence and poor prognosis of patients with OSCC.
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