期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 67, 期 -, 页码 44-50出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2019.01.016
关键词
Fructose; Corticosterone; Adrenal; 5 alpha-Reductase 1; 11 beta-Hydroxysteroid dehydrogenase type 2
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [17K07805, 18K05493]
- Grants-in-Aid for Scientific Research [17K07805, 18K05493] Funding Source: KAKEN
Global fructose consumption is on the rise; however, maternal high-fructose intake may have adverse effects on offspring. We previously demonstrated that excessive fructose intake by rat dams altered steroidogenic gene transcription in the hippocampus of offspring. Herein, we examined how maternal high-fructose intake influences the regulation of adrenal glucocorticoid levels in offspring. Rat dams received 20% fructose solution during gestation and lactation. After weaning, the offspring were provided normal water. Maternal high-fructose intake did not alter mRNA expression levels of adrenal corticosterone-synthesizing and corticosterone-inactivating proteins or the circulating adrenocorticotropic hormone levels of offspring at postnatal day (PD) 21; however, it increased circulating corticosterone levels and decreased mRNA and protein levels of adrenal 5 alpha-reductase type 1 and 11 beta-hydroxysteroid dehydrogenase type 2 in offspring at PD160. Furthermore, maternal high-fructose intake enhanced DNA methylation of the adrenal 5 alpha-reductase 1 promoter region in PD160 offspring. Thus, maternal high-fructose intake was found to affect adrenal steroid hormone clearance in adult offspring - at least in part - through epigenetic mechanisms. (C) 2019 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据