期刊
JOURNAL OF NEUROSCIENCE
卷 39, 期 26, 页码 5128-5142出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2590-18.2019
关键词
anterior cingulate cortex; brain oscillation; central poststroke pain; current source density; medial thalamus; morphine
资金
- Ministry of Science and Technology [105-2325-B-001-010, 105-2320-B-001-025-MY2, 106-2321-B-001-043]
- Academia Sinica
Prominent 7-12 Hz oscillations in frontal cortical networks in rats have been reported. However, the mechanism of generation and the physiological function of this brain rhythm have not yet been clarified. Multichannel extracellular field potentials of the ACC were recorded and analyzed using the current source density method in halothane-anesthetized rats. Spontaneous high-current spikes (HCSs) were localized in the deep part of layer II/III and upper part of layer V of the ACC. The frequency of HCSs in the ACC was 7-12 Hz, with an amplitude of 6.5 +/- 0.76 mV/mm(2) and duration of 55.24 +/- 2.43 ms. The power density significantly decreased (84.56 +/- 6.93%, p < 0.05, t test) after pinching the hindpaw and significantly increased (149.28 +/- 15.96%) after treatment with morphine. The suppressive effect of pinching was reversed by naloxone (0.7 mg/kg, i.p.). HCSs coincided with initiation of the depolarization of cingulate neurons and remained in a depolarized upstate. The occurrence of cingulate HCSs was persistently preceded by a hyperpolarization phase and a burst of multiunit spike activity in the medial dorsal thalamic nucleus. Spontaneous field-potential oscillations changed from 10 Hz to a lower band (i.e., similar to 7.5 Hz) when a central poststroke pain condition was induced. The central poststroke pain group had a higher average coherence coefficient compared with the control group. Our results indicate that spontaneous cingulate cortical HCSs could be initiated by thalamocortical synaptic inputs from the medial dorsal thalamic nucleus and maintained by intracortical neuronal upstate mechanisms in physiological and pathological pain states.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据