期刊
JOURNAL OF NEUROSCIENCE
卷 39, 期 29, 页码 5773-5793出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0213-19.2019
关键词
acid-sensing ion channel; ACC; chronic pain; long-term potentiation; protein kinase C
资金
- National Natural Science Foundation of China [81730095, 31771157, 91632304]
- Science and Technology Commission of Shanghai Municipality [18JC1420302]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX05]
- Shanghai Jiao Tong University School of Medicine Doctoral Innovation Fellowship [BXJ201901]
Chronic pain is a serious debilitating disease for which effective treatment is still lacking. Acid-sensing ion channel 1a (ASIC1a) has been implicated in nociceptive processing at both peripheral and spinal neurons. However, whether ASIC1a also contributes to pain perception at the supraspinal level remains elusive. Here, we report that ASIC1a in ACC is required for thermal and mechanical hypersensitivity associated with chronic pain. ACC-specific genetic deletion or pharmacological blockade of ASIC1a reduced the probability of cortical LTP induction and attenuated inflammatory thermal hyperalgesia and mechanical allodynia in male mice. Using cell type-specific manipulations, we demonstrate that ASIC1a in excitatory neurons of ACC is a major player in cortical LTP and pain behavior. Mechanistically, we show that ASIC1a tuned pain-related cortical plasticity through protein kinase C lambda-mediated increase of membrane trafficking of AMPAR subunit GluA1 in ACC. Importantly, postapplication of ASIC1a inhibitors in ACC reversed previously established nociceptive hypersensitivity in both chronic inflammatory pain and neuropathic pain models. These results suggest that ASIC1a critically contributes to a higher level of pain processing through synaptic potentiation in ACC, which may serve as a promising analgesic target for treatment of chronic pain.
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