期刊
JOURNAL OF NATURAL PRODUCTS
卷 82, 期 5, 页码 1387-1390出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b01097
关键词
-
资金
- Villum Foundation [VKR023285]
- Seventh Framework Program MaCuMBA from the European Union [KBBE-2012-6-311975]
- Seventh Framework Program PharmaSea from the European Union [KBBE-2012-6-312184]
- Danish National Research Foundation [DNRF137]
An S-methylated analogue of tropodithietic acid (TDA, 1), methyl troposulfenin (2), was isolated from the marine alphaproteobacterium Phaeobacter inhibens. The structure was elucidated by NMR and HRMS. Its inhibitory effect against the fish pathogen Vibrio anguillarum was 4-fold to 100-fold lower than that of the known antibacterial compound TDA. Methyl troposulfenin lacks the acidic proton of TDA, indicating that the methylation turns the potent antibacterial TDA into an inactive compound, and thereby, this analysis supports the proposed mode of action of TDA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据