期刊
JOURNAL OF NATURAL PRODUCTS
卷 82, 期 6, 页码 1714-1718出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00270
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资金
- Natural Science Foundation of Zhejiang Province, China [LQ19H300003]
- Public Project of Zhejiang Province, China [2017C37042]
- National Nature Science Foundation of China [81803580]
- Outstanding Youth Foundation from Wenzhou Medical University [604091809]
- Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences [201707]
Five new diterpenes, including an unprecedented 5,5,6,6,5-pentacyclic diterpene, sponalactone (1), two new spongian diterpenes, 17-O-acetylepispongiatriol (2) and 17-O-acetylspongiatriol (3), and two new spongian diterpene artifacts, 15 alpha,16 alpha-dimethoxy-15,16-dihydroepispongiatriol (4) and 15 alpha-ethoxyepispongiatrio1-16(15H)-one (5), were isolated from a South China Sea collection of the marine sponge Spongia officinalis, together with three known analogues (6-8). The structures of the new diterpenes were elucidated by extensive spectroscopic analysis. The absolute configurations were established on the basis of ECD data. Compounds 1-5 and 7 exhibited moderate inhibition against LPS-induced NO production in RAW264.7 macrophages with IC50 values of 12-32 mu M.
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