期刊
JOURNAL OF NATURAL PRODUCTS
卷 82, 期 5, 页码 1114-1119出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b00821
关键词
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资金
- Natural Science Foundation of Shandong Province [ZR2014HM018]
- National Natural Science Foundation of China [31741048]
Two new p-terphenyls, strepantibins A and B (1 and 2), along with the first representative of a naturally occurring bisphenyltropone, strepantibin C (3), were characterized from a Streptomyces sp. associated with the larvae of the mud dauber wasp Sceliphron madraspatanum. Their structures were determined by high-resolution electrospray ionization mass spectrometry, NMR, and X-ray crystallography data interpretation. Strepantibins A-C inhibited hexokinase II (HK2) activity and displayed antiproliferative activity against hepatoma carcinoma cells HepG-2, SMMC-7721 and plc-prf-5. In SMMC-7721 cells treated with strepantibin A, the morphological characteristics of apoptosis were observed.
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