期刊
JOURNAL OF NATURAL MEDICINES
卷 73, 期 4, 页码 820-825出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-019-01317-4
关键词
Antimalarial activity; Indole alkaloids; Tabernaemontana macrocarpa Jack
资金
- Ministry of Education, Culture, Sport, Science and Technology [17K15472, 15K18890, 16K08759]
- Sysmex Corporation
- Grants-in-Aid for Scientific Research [15K18890, 16K08759, 17K15472] Funding Source: KAKEN
Two new sarpagine-type indole alkaloids (1 and 2), together with five known alkaloids; 12-methoxy-4-methylvoachalotine (3), 16-demethoxycarbonylvoacamine (4), isositsirikine (5), affinisine (6), affinine (7), were isolated from the bark of Tabernaemontana macrocarpa Jack. The structures of these alkaloids were determined based on spectroscopic data, chemical correlation, and comparison with the literature. 16-Demethoxycarbonylvoacamine (4) showed antiplasmodial activities against Plasmodium falciparum 3D7 and cytotoxic activities against human cell line, HepG2 cells.
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