期刊
JOURNAL OF NATURAL MEDICINES
卷 73, 期 4, 页码 814-819出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-019-01315-6
关键词
Scrobiculoside; Deep-sea sponge; Pachastrella scrobiculosa; Cytotoxicity
资金
- Takeda Science Foundation
- Asahi Glass Foundation
- SUNBOR GRANT
- NOASTEC Foundation
- Akiyama Life Science Foundation
- Japan Agency for Medical Research and Development (AMED grant) [18061402]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan (JSPS KAKENHI) [JP16703511, JP18056499]
Two new steroidal saponins, scrobiculosides A and B, were isolated from the deep-sea sponge Pachastrella scrobiculosa, collected at a depth of 200 m off Miura Peninsula, Japan. The aglycones of scrobiculosides A and B feature a vinylic cyclopropane and a increment (24,25) exomethylene on the side chains, respectively. Both saponins have a common sugar moiety composed of beta-d-galactopyranosyl-(1 -> 2)-6-acetyl-beta-d-glucopyranoside, with the exception of an acetyl group on C6 '' in scrobiculoside A. Scrobiculoside A exhibited cytotoxicity against HL-60 and P388 cells, with IC50 values of 52 and 61 mu M, respectively.
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