期刊
JOURNAL OF MOLECULAR STRUCTURE
卷 1181, 期 -, 页码 287-294出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2018.12.109
关键词
Nickel(II) complex; Isothiosemicarbazone; Thiosemicarbazone; Ancillary ligand; Antimicrobial activity
资金
- Department of chemistry, at Payame Noor University (PNU)
- Ferdowsi University of Mashhad
- Abadan School of Medical Sciences
- Tulane University
Four new stable nickel(II) complexes (1-4) with isothiosemicarbazone- and thiosemicarbazone-based ligands, namely, salicylidine S-propyl-isothiosemicarbazone hydroiodide (H2L1 center dot HI), 5-bromo-2- hydroxybenzaldehyde S-propyl-isothiosemicarbazone hydroiodide (H2L2.HI), salicylidine- thiosemicarbazone (H2L3), and 5-bromo-2-hydroxybenzaldehyde thiosemicarbazone (H2L4) accompanied with triphenylphosphine and 2-methylimidazole as ancillary ligands were prepared in good yields. The complexes were characterized using analytical and spectroscopic techniques. Single-crystal X-ray crystallography revealed that the nickel complexes had distorted square planar geometries. H2L1 center dot HI and H2L2 center dot HI acted as NNO, while H2L3 and H2L4 acted as SNO tridentate donor ligands. In vitro antifungal and antibacterial activities of the Ni(II) complexes revealed that 3 exhibited the highest antifungal property especially against Candida albicans with an inhibition zone of 40 mm and a minimum inhibitory concentration, MIC = 1.56 mg/ml). Complex 2 showed the highest antibacterial property especially against Staphylococcus aureus with an inhibition zone of 30 mm and MIC of 1.56 mg/ml. Results indicate that these complexes are potential antimicrobial drugs for the treatment of infectious diseases for further research. (C) 2018 Elsevier B.V. All rights reserved.
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