期刊
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
卷 73, 期 -, 页码 142-151出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2019.01.017
关键词
Polymeric hydrogels; Hair keratin; Wound healing; Keratinocyte; Migration; Epithelial-Mesenchyme Transition
资金
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [NRF-2015M3A9E2028578, NRF-2010-0027963, NRF-2016R1D1A1B03 931933, NRF-2017-01410002]
- National Research Foundation of Korea [2015M3A9E2028578] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Recently, human hair-derived keratin protein has been recognized as biomaterial with high potential due to its excellent bioactivity and biocompatibility. Here, we designed human hair-derived keratin-based in situ cross-linkable hydrogels that can serve as a dynamic matrix for the enhanced wound healing. We demonstrated that our developed the keratin-based hydrogels accelerated re-epithelization and wound healing process in a full-thickness animal. Also, we investigated the molecular mechanism underlying the enhanced wound healing. In conclusion, our study proposes that human hair-derived keratin-based hydrogels with excellent bioactivity have great potential for use as a wound healing material, along with its other biomedical applications. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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