期刊
JOURNAL OF EXPERIMENTAL BOTANY
卷 70, 期 16, 页码 4251-4265出版社
OXFORD UNIV PRESS
DOI: 10.1093/jxb/erz225
关键词
beta-Cyanoalanine synthase; cyanide; L-cysteine desulfhydrase; persulfidation; redox regulation; S-cyanylation; sulfide; thiol group
资金
- European Regional Development Fund through the Agencia Estatal de Investigacion [BIO2016-76633-P]
- European Social Fund through the Formacion de Doctores of the Agencia Estatal de Investigacion program
Two cysteine metabolism-related molecules, hydrogen sulfide and hydrogen cyanide, which are considered toxic, have now been considered as signaling molecules. Hydrogen sulfide is produced in chloroplasts through the activity of sulfite reductase and in the cytosol and mitochondria by the action of sulfide-generating enzymes, and regulates/affects essential plant processes such as plant adaptation, development, photosynthesis, autophagy, and stomatal movement, where interplay with other signaling molecules occurs. The mechanism of action of sulfide, which modifies protein cysteine thiols to form persulfides, is related to its chemical features. This post-translational modification, called persulfidation, could play a protective role for thiols against oxidative damage. Hydrogen cyanide is produced during the biosynthesis of ethylene and camalexin in non-cyanogenic plants, and is detoxified by the action of sulfur-related enzymes. Cyanide functions include the breaking of seed dormancy, modifying the plant responses to biotic stress, and inhibition of root hair elongation. The mode of action of cyanide is under investigation, although it has recently been demonstrated to perform post-translational modification of protein cysteine thiols to form thiocyanate, a process called S-cyanylation. Therefore, the signaling roles of sulfide and most probably of cyanide are performed through the modification of specific cysteine residues, altering protein functions. Sulfide and cyanide are considered signaling molecules, acting through post-translational modification of cysteine residues of proteins.
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