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Molecular pattern of lncRNAs in hepatocellular carcinoma

出版社

BMC
DOI: 10.1186/s13046-019-1213-0

关键词

lncRNA; Molecular pattern; Regulation of biological processes; Hepatocellular carcinoma; Well-characterized mechanism

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资金

  1. General Programs from the National Natural Science Foundation of China [81472618, 81670535]
  2. National Science and Technology Major Project [2017ZX10202202, 2018ZX10301202]
  3. Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01S131]
  4. Innovative Research Team Project of Guangxi Province [2017GXNSFGA198002]
  5. Grant for Recruited Talents to Start Scientific Research from Nanfang Hospital
  6. Distinguished Youth Scholars Incubation Project of Nanfang Hospital [2017 J001]

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Hepatocellular carcinoma (HCC) is one of the most notable lethal malignancies worldwide. However, the molecular mechanisms involved in the initiation and progression of this disease remain poorly understood. Over the past decade, many studies have demonstrated the important regulatory roles of long non-coding RNAs (lncRNAs) in HCC. Here, we comprehensively review recent discoveries regarding HCC-associated lncRNA functions, which we have classified and described according to their mechanism models.

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