期刊
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
卷 839, 期 -, 页码 202-209出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jelechem.2019.03.051
关键词
Poly (indole-5-carboxylic acid); Poly (3, 4-ethylenedioxythiophene); Prostate specific antigen; Biomarker; Electrochemical immunosensor
资金
- National Natural Science Foundation of China [21665010, 51862014, 31741103, 51572117, 51302117]
- 5511 Science and Technology Innovation Talent Project of Jiangxi Province [20162BCB23027, 20165BCB18016]
- Department of Education, Jiangxi Province [GJJ12595]
- Natural Science Foundation of Jiangxi Province [20171BAB203015]
- outstanding youth fund of Jiangxi Province [20162BCB23027, 20165BCB18016]
In this paper, core-shell structured poly (indole-5-carboxylic acid) @ poly (3, 4-ethylenedioxythiophene) (PIn-5-COOH@PEDOT) composite was prepared by a facile two-step chemical oxidation method. The composite possesses large specific surface area, high stability, good electrical conductivity and redox activity, which was designed as label-free electrochemical immunosensing platform for the monitor of the prostate specific antigen (PSA). In this sensing system, PIn-5-COOH served as both signal molecule and antibody carrier. The coating PEDOT was used to enhance the conductivity and stability of PIn-5-COOH. Benefiting from the synergistic effects between PIn-5-COOH and PEDOT, the fabricated immunosensor exhibited a wide linear range of 0.01-25 ng mL(-1) and low detection limit of 3.4 pg mL(-1) (S/N = 3) for the assay of PSA, coupled with good selectivity, reproducibility and stability. The immunosensor is simple, sensitive, specific and reproducible, which could provide a potential approach for clinical diagnosis.
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