期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 52, 期 -, 页码 986-996出版社
ELSEVIER
DOI: 10.1016/j.jddst.2019.05.034
关键词
Solubility improvement; Drug delivery; Inorganic carrier; Adsorption; Intercalation
The aim of this work was to develop and characterize different Layered Double Hydroxides (LDHs) loaded with of Olanzapine (OLZ), CaAl:OLZ and NiAl:OLZ, by thermogravimetry (TG), differential scanning calorimetry (DSC), Fourier Transform Infrared spectroscopy (FT-IR) and X-ray diffraction (XRD), dissolution rate improvement, inhibition of AAPH-induced hemolysis and toxicity prospections with Anemia salina assay. No peaks of OLZ were found on diffractograms of both systems (5%) indicating amorphization of OLZ. This behavior was decreased with the increasing of drug. FT-IR spectra showed decreasing, displacements, suppressions and enlargements of bands in specific regions suggesting OLZ intercalation in both HDLs. No OLZ endothermic events was found in DSC curves indicating a decrease in the drug crystallinity, excepting for samples with 30% of OLZ. The dissolution profile evidenced that in 45 min CaAl:OLZ 5% and NiAl:OLZ 5% presented the maximum drug solubilization of 89.08 and 61.66%, respectively. In the inhibition of AAPH-induced hemolysis, both systems, showed significant inhibition (p <= 0.05) compared to the negative control, and Anemia salina assay evidenced that both HDLs (5%) did not cause the significant death of the specimens compared to OLZ in 24 h. The exposed results reinforced the proposed use of LDHs as functional excipients.
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