期刊
ANNALS OF ONCOLOGY
卷 27, 期 8, 页码 1449-1455出版社
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdw142
关键词
BRCA; somatic mutation; methylation; ovarian cancer
类别
资金
- Royal Marsden and Institute of Cancer Research National Institute for Health Research (NIHR)
- Biomedical Research Centre for Cancer (BRC)
- Gynaecological Cancers Fund
- European School of Oncology
This article summarises the evolving role and challenges of somatic BRCA mutations and BRCA methylation in ovarian cancer.The significant activity of poly(ADP-ribose)polymerase (PARP) inhibitors in the treatment of germline BRCA mutation-associated ovarian cancer, which represents similar to 15% of HGS cases, has recently led to European Medicines Agency and food and drug administration approval of olaparib. Accumulating evidence suggests that PARP inhibitors may have a wider application in the treatment of sporadic ovarian cancers. Up to 50% of HGS ovarian cancer patients may exhibit homologous recombination deficiency (HRD) through mechanisms including germline BRCA mutations, somatic BRCA mutations, and BRCA promoter methylation. In this review, we discuss the role of somatic BRCA mutations and BRCA methylation in ovarian cancer. There is accumulating evidence for routine somatic BRCA mutation testing, but the relevance of BRCA epigenetic modifications is less clear. We explore the challenges that need to be addressed if the full potential of these markers of HRD is to be utilised in clinical practice.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据