Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy

The tumor microenvironment (TME) is an integral part of cancer, acting as a complex ecosystem supporting tumor growth and metastatic dissemination while attenuating immunosurveillance. In this review, we describe the composition of the TME and how this attenuates antitumor immune responses, and discuss the existing and upcoming strategies aimed at targeting cellular and molecular TME components.The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of cancer development to the concept of a complex tumor ecosystem that supports tumor growth and metastatic dissemination. Accordingly, novel targets within the TME have been uncovered that can help direct and improve the actions of various cancer therapies, notably immunotherapies that work by potentiating host antitumor immune responses. Here, we review the composition of the TME, how this attenuates immunosurveillance, and discuss existing and potential strategies aimed at targeting cellular and molecular TME components.