期刊
JOURNAL OF CONTROLLED RELEASE
卷 301, 期 -, 页码 157-165出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2019.03.019
关键词
Tumor acidity; Magnetic nanotheranostics; Charge-conversion; Photodynamic therapy; MR/NIRF imaging
资金
- National Natural Science Foundation of China (NSFC) [21805108, 51473023]
- Science and Technology Innovation Development Program of Jilin City [201831747, 201831749]
- Basic Science Research Program through a National Research Foundation of Korea - Korean Government (MEST) [NRF-2017R1A5A1070259]
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2017R1D1A1B03033988]
Nanosized self-assemblies built from inorganic nanoparticles and polymer ligands have the potential to generate personalized theranostics systems for diagnostic imaging and cancer therapy. However, most of the theranostics systems suffer from poor targeting activity, insensitive diagnosis and drug leakage, leading to poor treatment results. In this study, a hierarchical tumor acidity-responsive magnetic nanobomb (termed HTAMN) was developed for photodynamic therapy and diagnostic imaging. The HTAMNs were formed through the self-assembly of chlorin e6 (Ce6)-functionalized polypeptide ligand, methoxy poly (ethyleneglycol)-block-poly (dopamineethylenediamine-2,3-dimethylmaleic anhydride)-L-glutamate-Ce6 [mPEG-b-P (Dopa-Ethy-DMMA)LG-Ce6] and superparamagnetic iron oxide nanoparticles (SPIONs). Negatively charged HTAMNs circulate in the blood for prolonged periods and promote tumor retention by passive targeting to the tumor. Once the HTAMNs arrive at the tumor location, the acidic extracellular tumor environment reverses the surface charge of the HTAMNs, resulting in tumor accumulation and cellular uptake. Moreover, in response to the more acidic environment inside cells, the photosensitizers are activated resulted in enhanced diagnostic imaging and cancer treatment. The in vitro and in vivo results indicate the effective tumor accumulation, internalization, diagnostic sensitivity and superior photodynamic therapy effect of the HTAMNs. Therefore, designing smart HTAMNs can promote the rapid development of cancer theranostics for clinical implementation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据