期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 21, 期 1, 页码 8-15出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2014.10.026
关键词
Acute myeloid leukemia; Leukemic stem/progenitor cell; Conditioning regimen; Reduced-intensity conditioning; Graft-versus-leukemia; Disease relapse
资金
- Celgene
Allogeneic stem cell transplantation is an increasingly important treatment option in the management of adult acute myeloid leukemia (AML). The major causes of treatment failure remain disease relapse and treatment toxicity. In this review, Dr Vyas presents an overview of important recent data defining molecular factors associated with treatment failure in AML. He also identifies the emerging importance of leukemia stem cell biology in determining both response to therapy and relapse risk in AML. Dr Appelbaum discusses advances in the design and delivery of both myeloablative and reduced-intensity conditioning regimens, highlighting novel strategies with the potential to improve outcome. Dr Craddock discusses the development of both novel conditioning regimens and post-transplantation strategies aimed at reducing the risk of disease relapse. (C) 2015 American Society for Blood and Marrow Transplantation.
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