Gamma Delta T Cell Reconstitution Is Associated with Fewer Infections and Improved Event-Free Survival after Hematopoietic Stem Cell Transplantation for Pediatric Leukemia

After hematopoietic stem cell transplantation (HSCT), successful engraftment and immune recovery is necessary to protect the patient from relapse and infection. Many studies highlight the importance of conventional alpha beta T cell recovery after HSCT, but the impact of gamma delta T cell recovery has not been well described. Here, we investigate the recovery of gamma delta T cells in 102 pediatric patients with acute leukemia in first clinical remission who underwent allogeneic HSCT at St. Jude Children's Research Hospital from 1996 to 2011. Mean patient age was 10.5 +/- 5.9 years (range, .6 to 25.2), and mean survivor follow-up was 2.7 +/- 1.8 years (range, .12 to 6.0). Diagnoses included 59% patients with acute lymphoblastic leukemia and 41% patients with acute myelogenous leukemia. Multivariate analysis demonstrated significant impact of the maximum number of CD3(+), CD4(+), and CD8(+) T cells and donor source on the gamma delta T cell recovery (P < .0001, P < .0001, P < .0001, and P < .004, respectively). Univariate and multivariate models found the number of gamma delta T cells after HSCT to be associated with infections (P = .026 and P = .02, respectively). We found the probability of infections for patients with an elevated number of gamma delta T cells was significantly lower compared with patients with low or normal gamma delta T cells after HSCT (18% versus 54%; P = .025). Bacterial infections were not observed in patients with elevated gamma delta T cells. Finally, event-free survival was significantly higher in patients with enhanced gamma delta T cell reconstitution compared with patients with low/normal gamma delta T cell reconstitution after HSCT (91% versus 55%; P = .04). Thus, gamma delta T cells may play an important role in immune reconstitution after HSCT. (C) 2015 American Society for Blood and Marrow Transplantation.