期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 129, 期 6, 页码 2485-2499出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI125646
关键词
-
资金
- German Research Fund [RO4856/1-2, CRC1052 C05]
- European Foundation for the Study of Diabetes on New Targets for Type 2 Diabetes
- MSD [96403]
- Federal Ministry of Education and Research, Germany (FKZ) [01EO1501]
- Horizon 2020 Research and Innovation Program MCIF [655598]
- PRC Scholarship Council [201808080208]
- Wisconsin National Primate Research Center Nonhuman Primate Biological Materials Distribution Core [P51OD011106]
Prevalence of obesity among infants and children below 5 years of age is rising dramatically, and early childhood obesity is a forerunner of obesity and obesity-associated diseases in adulthood. Childhood obesity is hence one of the most serious public health challenges today. Here, we have identified a mother-to-child lipid signaling that protects from obesity. We have found that breast milk-specific lipid species, so-called alkylglycerol-type (AKG-type) ether lipids, which are absent from infant formula and adult-type diets, maintain beige adipose tissue (BeAT) in the infant and impede the transformation of BeAT into lipid-storing white adipose tissue (WAT). Breast milk AKGs are metabolized by adipose tissue macrophages (ATMs) to platelet-activating factor (PAF), which ultimately activates IL-6/STAT3 signaling in adipocytes and triggers BeAT development in the infant. Accordingly, lack of AKG intake in infancy leads to a premature loss of BeAT and increases fat accumulation. AKG signaling is specific for infants and is inactivated in adulthood. However, in obese adipose tissue, ATMs regain their ability to metabolize AKGs, which reduces obesity. In summary, AKGs are specific lipid signals of breast milk that are essential for healthy adipose tissue development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据