4.2 Article

Eucalyptus Sideroxylon Bark Anti-inflammatory Potential, Its UPLC-PDA-ESI-qTOF-MS Profiling, and Isolation of a New Phloroglucinol

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JOURNAL OF CHROMATOGRAPHIC SCIENCE
卷 57, 期 6, 页码 565-574

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OXFORD UNIV PRESS INC
DOI: 10.1093/chromsci/bmz029

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UPLC-MS; 7'-deoxyguajavadial A; methyl morolate; membrane stabilization

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Eucalyptus barks contain complex biomass of constituents with considerable chemical and structural diversity. Reports about Eucalyptus sideroxylon Cunn. ex Woolls bark composition and biological activities are limited. Non-targeted metabolomic analysis via ultra-performance liquid chromatography-quadrupole-time-of-flight-photodiode array-mass spectrometry (UPLC-qTOF-PDA-MS) enabled first-time detection of 41 secondary metabolites of which 31 were identified including; 6 flavonoids, 4 ellagic acid derivatives, 8 triterpenes, 10 fatty acids and 3 miscellaneous. The isolation and structure elucidation of methyl morolate, beta-sitosterol, syringaldeyhde and 7'-deoxyguajavadial A were reported. The bark methylene chloride: methanol (8:2) extract demonstrated significant (P < 0.01) in vitro anti-inflammatory activity through membrane stabilization, protein denaturation inhibition, anti-lipoxygenase, and proteinase inhibition assays. The strongest anti-inflammatory activity was via membrane stabilization (34.4%) as compared to diclofenac sodium (26%) at the same concentration (125 mu g/mL). Our study represents the sole complete map for E. sideroxylon bark components and represents it as new anti-inflammatory drug.

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