期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 23, 期 6, 页码 4443-4453出版社
WILEY
DOI: 10.1111/jcmm.14340
关键词
Adriamycin nephropathy; podocytes; salidroside; beta-catenin
资金
- National Key Research and Development Program of China [2017YFA0701304]
- National Natural Science Foundation of China [81770841]
- Health and Family Planning Commission research projects of Jiangsu [H201522]
- Science and Technology Foundation of Nantong [BK2013006]
- Dr. Scientific Research Foundation of Nantong University [14B40]
Salidroside is a major phenylethanoid glycoside in Rhodiola rosea L., a traditional Chinese medicine, with multiple biological activities. It has been shown that salidroside possesses protective effects for alleviating diabetic renal dysfunction, contrastinduced-nephropathy and other kidney diseases. However, the involved molecular mechanism was still not understood well. Herein, we examined the protective effects of salidroside in mice with Adriamycin (ADR)-induced nephropathy and the underlying molecular mechanism. The results showed that salidroside treatment ameliorates proteinuria; improves expressions of nephrin and podocin; and reduces kidney fibrosis and glomerulosclerosis induced by ADR. Mechanistically, ADR induces a robust accumulation of beta-catenin in the nucleus and stimulates its downstream target gene expression. The application of salidroside largely abolishes the nuclear translocation of beta-catenin and thus inhibits its activity. Furthermore, the activation of beta-catenin almost completely counteracts the protective roles of salidroside in ADR-injured podocytes. Taken together, our data indicate that salidroside ameliorates proteinuria, renal fibrosis and podocyte injury in ADR nephropathy, which may rely on inhibition of beta-catenin signalling pathway.
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