期刊
JOURNAL OF BIONIC ENGINEERING
卷 16, 期 2, 页码 189-208出版社
SPRINGER SINGAPORE PTE LTD
DOI: 10.1007/s42235-019-0017-4
关键词
electrospinning; nanofibers; bio-mimicking; stem cells; bioactive molecules; regenerative medicine
资金
- DST Nano Mission [SR/NM/NM-1038/2016]
- Science and Engineering Research Board (SERB) [ECR/2016/001429]
- Korea Institute of Energy Technology Evaluation and Planning (KETEP)
- Ministry of Trade, Industry & Energy (MOTIE) of the Republic of Korea [20174010201160]
Opening up new and unlimited avenues in the biomedical field, tissue engineering and regenerative medicine, the electrospinning process is considered as a versatile and the most preferred technique for the fabrication of nanofibers. These tailor-designed nanofibers provide a desirable and bio-inspired physiological niche to cells for better attachment and subsequent proliferation. In this review, an attempt is made to explain the importance of various topological and morphological parameters of nanofibrous scaffolds for efficient bio-mimicking. Some novel approaches (e.g., appropriate functionalization and extracellular matrix derived from decellularization) utilized for better mimicking and exponential growth of regenerating tissues are also discussed. Furthermore, this review highlights the important parameters necessary for the attachment, proliferation and differentiation of the mesenchymal stem cells for tissue regeneration. The importance of growth factors and their role after introducing the electrospinning techniques for efficient delivery and their role in the proliferation of mesenchymal stem cells in the different specific lineage (e.g., tenogenic, chondrogenic, neurogenic and osteogenic differentiation) are discussed.
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