期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 68, 期 7, 页码 1780-1789出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b01687
关键词
metabolomics; gut microbiota; intestinal permeability; nutrients; polyphenols; aging
资金
- Spanish Ministry of the Economy and Competitiveness (MINECO) [MAPLE-PCIN-2015-238, 8245/7303/2016]
- Biotechnology and Biological Sciences Research Council (U.K.) [BB/R012512/1]
- MAPLE Gut and Blood Microbiomics
- CIBERFES - European Regional Development Fund (FEDER) program from the European Union (EU)
- Generalitat de Catalunya's Agency for Management of University and Research Grants (AGAUR) [2017SGR1566]
- Juan de la Cierva program from MINECO [FJCI-2015-26590]
- ICREA under the ICREA Academia program
- BBSRC [BB/N023951/1, BBS/E/F/000PR10343, BBS/E/F/00044434, BBS/E/F/000PR10346, BBS/E/F/000PR10347] Funding Source: UKRI
The gut microbiota is involved in the regulation of the intestinal permeability (IP), whose disruption is a frequent condition in older people and is associated with the development of several diseases. The diet can affect the gut microbiota and IP, although the molecular / mechanisms involved are unclear. Metabolomics is one of the suitable approaches to study the effects of diet on gut microbiota and IP, although, up to now, the research has focused only on a few dietary components. The aim here was to review the most recent literature concerning the application of metabolomics to the study of the diet-induced alterations of gut microbiota and the effects on IP, with a particular focus on the molecular pathways involved. An additional aim was to give a perspective on the future research involving dietary polyphenols, because despite their potential use in the management of increased IP, few studies have been reported to date.
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