期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/ijms20081979
关键词
SUDEP; epilepsy; genetics
资金
- Obra Social La Caixa
- Fondo Investigacion Sanitaria from Instituto Salud Carlos III (ISCIII) [PI17/01690]
- Fundacio Privada Daniel Bravo Andreu
- Fondi Linea D1-Universita Cattolica del Sacro Cuore, Italy
Epilepsy is a common neurological disorder associated with increased morbidity and mortality. Sudden unexpected death in epilepsy, also known as SUDEP, is the main cause of death in patients with epilepsy. SUDEP has an incidence of 1.2 per 1000 person-years in adults and 0.2 per 1000 person-years in children. SUDEP accounts for 8-17% of deaths in patients with epilepsy. It is commonly associated with a history of generalized tonic-clonic seizures, and its risk may be increased by other factors such as postictal electroencephalographic suppression, prone sleeping position, altered heart rate variability, conduction abnormalities, gender, or antiepileptic medications. Recently, electrocardiograms, electroencephalograms, and imaging markers have helped clinicians stratify SUDEP risk and identify patients in need of close monitoring. However, the pathophysiology of SUDEP is likely multifactorial and still unknown. Improving the knowledge of SUDEP incidence, risk factors, and biomarkers can help design and implement effective prevention strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据