相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Structure function relations in PDZ-domain-containing proteins: Implications for protein networks in cellular signalling
G. P. Manjunath et al.
JOURNAL OF BIOSCIENCES (2018)
HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease
Veronick Benoy et al.
BRAIN (2018)
Casein kinase 1α: biological mechanisms and theranostic potential
Shaojie Jiang et al.
CELL COMMUNICATION AND SIGNALING (2018)
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome
Elisa Landucci et al.
EXPERIMENTAL CELL RESEARCH (2018)
Histone deacetylases (HDACs) as therapeutic target for depressive disorders
Paulina Misztak et al.
PHARMACOLOGICAL REPORTS (2018)
The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer's disease model
Sheng-Jun Fan et al.
CELL DEATH & DISEASE (2018)
Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy
Zhongying Mo et al.
NATURE COMMUNICATIONS (2018)
HDAC6 as a potential therapeutic target for peripheral nerve disorders
Robert Prior et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2018)
The HDAC6 Inhibitor Trichostatin A Acetylates Microtubules and Protects Axons From Excitotoxin-Induced Degeneration in a Compartmented Culture Model
Kelsey Hanson et al.
FRONTIERS IN NEUROSCIENCE (2018)
Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines
Joanne H. Huang et al.
JOURNAL OF PROTEOME RESEARCH (2017)
Induced pluripotent stem cell technology: a decade of progress
Yanhong Shi et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease
Veronick Benoy et al.
NEUROTHERAPEUTICS (2017)
Introduction to Special Issue on Animal Models of Neuropsychiatric Disorders and Substance Use Disorders: Progress and Gaps
Mark A. Smith et al.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY (2017)
Stem cell-derived neurons in the development of targeted treatment for schizophrenia and bipolar disorder
Bradley Watmuff et al.
PHARMACOGENOMICS (2017)
Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function
Naoe T. Nihira et al.
SCIENCE SIGNALING (2017)
HDAC6 inhibition by tubastatin A is protective against oxidative stress in a photoreceptor cell line and restores visual function in a zebrafish model of inherited blindness
Janina Leyk et al.
CELL DEATH & DISEASE (2017)
Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability
Jasmin Lalonde et al.
NATURE COMMUNICATIONS (2017)
HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
Wenting Guo et al.
NATURE COMMUNICATIONS (2017)
The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology
Jui-Heng Tseng et al.
CELL REPORTS (2017)
Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function
Naoe T. Nihira et al.
SCIENCE SIGNALING (2017)
HDAC6 Brain Mapping with [18F] Bavarostat Enabled by a RuMediated Deoxyfluorination
Martin G. Strebl et al.
ACS CENTRAL SCIENCE (2017)
Small-molecule Modulation of HDAC6 Activity: The Propitious Therapeutic Strategy to Vanquish Neurodegenerative Disorders
Shabir A. Ganai
CURRENT MEDICINAL CHEMISTRY (2017)
Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells
Jonathan Iaconelli et al.
ACS CHEMICAL BIOLOGY (2017)
Animal models for neuropsychiatric disorders: prospects for circuit intervention
Tobias Kaiser et al.
CURRENT OPINION IN NEUROBIOLOGY (2017)
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
Roel Nusse et al.
CELL (2017)
Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease
Sida Shen et al.
ACS CHEMICAL NEUROSCIENCE (2016)
Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent
Nivanthika K. Wimalasena et al.
ACS CHEMICAL NEUROSCIENCE (2016)
Protein aggregate formation in oligodendrocytes: tau and the cytoskeleton at the intersection of neuroprotection and neurodegeneration
Christiane Richter-Landsberg
BIOLOGICAL CHEMISTRY (2016)
Ketamine-induced inhibition of glycogen synthase kinase-3 contributes to the augmentation of α-amino-3-hydroxy-5-methylisoxazole--4-propionic acid (AMPA) receptor signaling
Eleonore Beurel et al.
BIPOLAR DISORDERS (2016)
Disease signatures for schizophrenia and bipolar disorder using patient-derived induced pluripotent stem cells
Bradley Watmuff et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2016)
Stem cell models of neuropsychiatric disorders
Rakesh Karmacharya et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2016)
The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression
Elsa M. Meylan et al.
NEUROPHARMACOLOGY (2016)
Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress
Jing Sun et al.
NEUROSCIENCE LETTERS (2016)
Ligand binding to the PDZ domains of postsynaptic density protein 95
Angelo Toto et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2016)
Limitations in Translating Animal Studies to Humans in Cardiovascular Disease
Sean Lal et al.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2016)
HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation
Ji-Yon Kim et al.
STEM CELLS INTERNATIONAL (2016)
HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of β-Catenin in Human iPSC-Derived Neuronal Cells
Jonathan Iaconelli et al.
ACS CHEMICAL BIOLOGY (2015)
Enhancement of Stress Resilience Through Histone Deacetylase 6-Mediated Regulation of Glucocorticoid Receptor Chaperone Dynamics
Jeanine Jochems et al.
BIOLOGICAL PSYCHIATRY (2015)
PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia
Laura A. Jansen et al.
BRAIN (2015)
The Flaws and Human Harms of Animal Experimentation
Aysha Akhtar
CAMBRIDGE QUARTERLY OF HEALTHCARE ETHICS (2015)
Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes
Wen-Jie Bian et al.
CELL (2015)
Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1
ChangHui Pak et al.
CELL STEM CELL (2015)
Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro
Peter Kirwan et al.
DEVELOPMENT (2015)
Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity
M. Erburu et al.
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2015)
Selective disruption of dopamine D2-receptors/beta-arrestin2 signaling by mood stabilizers
Thomas Del' Guidice et al.
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2015)
Valproic Acid Arrests Proliferation but Promotes Neuronal Differentiation of Adult Spinal NSPCs from SCI Rats
Weihua Chu et al.
NEUROCHEMICAL RESEARCH (2015)
Uncoupling of Protein Aggregation and Neurodegeneration in a Mouse Amyotrophic Lateral Sclerosis Model
Joo-Yong Lee et al.
NEURODEGENERATIVE DISEASES (2015)
Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue
Gavin Rumbaugh et al.
NEUROPSYCHOPHARMACOLOGY (2015)
ANTIDEPRESSANT ACTION OF HDAC INHIBITION IN THE PREFRONTAL CORTEX
H. E. Covington et al.
NEUROSCIENCE (2015)
Cadherins and catenins in dendrite and synapse morphogenesis
Eunju Seong et al.
CELL ADHESION & MIGRATION (2015)
Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in a transgenic mouse model of amyotrophic lateral sclerosis
Sheng Chen et al.
NEUROSCIENCE BULLETIN (2015)
MeCP2 deficiency is associated with reduced levels of tubulin acetylation and can be restored using HDAC6 inhibitors
W. A. Gold et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2015)
Inhibition of HDAC6 Modifies Tau Inclusion Body Formation and Impairs Autophagic Clearance
Janina Leyk et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2015)
Loss of neuronal GSK3 beta reduces dendritic spine stability and attenuates excitatory synaptic transmission via beta-catenin
S. M. Ochs et al.
MOLECULAR PSYCHIATRY (2015)
Loss of TDP-43 Inhibits Amyotrophic Lateral Sclerosis-Linked Mutant SOD1 Aggresome Formation in an HDAC6-Dependent Manner
Qin Xia et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions
Yonglin Gao et al.
PHARMACOLOGY RESEARCH & PERSPECTIVES (2015)
Regulation of Akt Signaling by Sirtuins Its Implication in Cardiac Hypertrophy and Aging
Vinodkumar B. Pillai et al.
CIRCULATION RESEARCH (2014)
HDAC signaling in neuronal development and axon regeneration
Yongcheol Cho et al.
CURRENT OPINION IN NEUROBIOLOGY (2014)
The Wnt Cries Many: Wnt Regulation of Neurogenesis Through Tissue Patterning, Proliferation, and Asymmetric Cell Division
Holger Bielen et al.
DEVELOPMENTAL NEUROBIOLOGY (2014)
HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes
Monika Noack et al.
GLIA (2014)
Tubastatin A/ACY-1215 Improves Cognition in Alzheimer's Disease Transgenic Mice
Ling Zhang et al.
JOURNAL OF ALZHEIMERS DISEASE (2014)
Sirt2 Deacetylase Is a Novel AKT Binding Partner Critical for AKT Activation by Insulin
Gopalakrishnan Ramakrishnan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Histone deacetylase 3 as a novel therapeutic target in multiple myeloma
J. Minami et al.
LEUKEMIA (2014)
β-catenin mediates stress resilience through Dicer1/microRNA regulation
Caroline Dias et al.
NATURE (2014)
Antidepressant-Like Properties of Novel HDAC6-Selective Inhibitors with Improved Brain Bioavailability
Jeanine Jochems et al.
NEUROPSYCHOPHARMACOLOGY (2014)
EPIGENETIC MECHANISMS IN MOOD DISORDERS: TARGETING NEUROPLASTICITY
D. M. Fass et al.
NEUROSCIENCE (2014)
Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition
Maj-Linda Selenica et al.
ALZHEIMERS RESEARCH & THERAPY (2014)
HDAC6 Is a Bruchpilot Deacetylase that Facilitates Neurotransmitter Release
Katarzyna Miskiewicz et al.
CELL REPORTS (2014)
A role for histone deacetylases in the cellular and behavioral mechanisms underlying learning and memory
Melissa Mahgoub et al.
LEARNING & MEMORY (2014)
Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration
Christiane Richter-Landsberg et al.
ACTA NEUROPATHOLOGICA (2013)
Histone deacetylase (HDAC) inhibitors as single agents induce multiple myeloma cell death principally through the inhibition of class I HDAC
Sridurga Mithraprabhu et al.
BRITISH JOURNAL OF HAEMATOLOGY (2013)
Family-wide Investigation of PDZ Domain-Mediated Protein-Protein Interactions Implicates β-Catenin in Maintaining the Integrity of Tight Junctions
Taranjit S. Gujral et al.
CHEMISTRY & BIOLOGY (2013)
Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease
Nambirajan Govindarajan et al.
EMBO MOLECULAR MEDICINE (2013)
Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS
Ines Taes et al.
HUMAN MOLECULAR GENETICS (2013)
HDAC6 Regulates Mutant SOD1 Aggregation through Two SMIR Motifs and Tubulin Acetylation
Jozsef Gal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
Sam A. Golden et al.
NATURE MEDICINE (2013)
AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development
Jianing Zhang et al.
NEURAL DEVELOPMENT (2013)
Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity
Daniel M. Fass et al.
NEUROPHARMACOLOGY (2013)
GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine
Rong-Jian Liu et al.
NEUROPSYCHOPHARMACOLOGY (2013)
A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests
Frederick A. Schroeder et al.
PLOS ONE (2013)
Genomic responses in mouse models poorly mimic human inflammatory diseases
Junhee Seok et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma
Loredana Santo et al.
BLOOD (2012)
Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain-derived neurotrophic factor, β-catenin and antidepressant-like effects
F. Pilar-Cuellar et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
The many faces and functions of β-catenin
Tomas Valenta et al.
EMBO JOURNAL (2012)
Protein levels of beta-catenin and activation state of glycogen synthase kinase-3 beta in major depression. A study with postmortem prefrontal cortex
Felicien Karege et al.
JOURNAL OF AFFECTIVE DISORDERS (2012)
Animal models: Not close enough
Jocelyn Rice
NATURE (2012)
The dynamic role of beta-catenin in synaptic plasticity
Kimberly A. Maguschak et al.
NEUROPHARMACOLOGY (2012)
Loss of Deacetylation Activity of Hdac6 Affects Emotional Behavior in Mice
Masahide Fukada et al.
PLOS ONE (2012)
GSK-3 and Wnt signaling in neurogenesis and bipolar disorder
Alexander J. Valvezan et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2012)
Histone Deacetylases and Mood Disorders: Epigenetic Programming in Gene-Environment Interactions
Rodrigo Machado-Vieira et al.
CNS NEUROSCIENCE & THERAPEUTICS (2011)
An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons
Devi Majumdar et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2011)
Synapse microarray identification of small molecules that enhance synaptogenesis
Peng Shi et al.
NATURE COMMUNICATIONS (2011)
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
Fabienne C. Fiesel et al.
EMBO JOURNAL (2010)
Amyotrophic Lateral Sclerosis-associated Proteins TDP-43 and FUS/TLS Function in a Common Biochemical Complex to Co-regulate HDAC6 mRNA
Sang Hwa Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A
Kyle V. Butler et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Chemical phylogenetics of histone deacetylases
James E. Bradner et al.
NATURE CHEMICAL BIOLOGY (2010)
Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
Sang-Won Min et al.
NEURON (2010)
Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?
Xiaohua Li et al.
NEUROPSYCHOPHARMACOLOGY (2010)
β-Catenin Phosphorylated at Serine 45 Is Spatially Uncoupled from β-Catenin Phosphorylated in the GSK3 Domain: Implications for Signaling
Meghan T. Maher et al.
PLOS ONE (2010)
Can Animal Models of Disease Reliably Inform Human Studies?
H. Bart van der Worp et al.
PLOS MEDICINE (2010)
Antidepressant Actions of Histone Deacetylase Inhibitors
Herbert E. Covington et al.
JOURNAL OF NEUROSCIENCE (2009)
PCAF Acetylates beta-Catenin and Improves Its Stability
Xinjian Ge et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Coordinated Changes in Dendritic Arborization and Synaptic Strength during Neural Circuit Development
Yi-Rong Peng et al.
NEURON (2009)
Clozapine Interaction with Phosphatidyl Inositol 3-Kinase (PI3K)/Insulin-Signaling Pathway in Caenorhabditis elegans
Rakesh Karmacharya et al.
NEUROPSYCHOPHARMACOLOGY (2009)
HDAC6 is a target for protection and regeneration following injury in the nervous system
Mark A. Rivieccio et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Chunaram Choudhary et al.
SCIENCE (2009)
Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease
Susanna Pietropaolo et al.
BEHAVIORAL NEUROSCIENCE (2008)
Generation and behavioral characterization of β-catenin forebrain-specific conditional knock-out mice
Todd D. Gould et al.
BEHAVIOURAL BRAIN RESEARCH (2008)
HDAC6 is required for epidermal growth factor-induced β-catenin nuclear localization
Yu Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas
S. Balasubramanian et al.
LEUKEMIA (2008)
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
Kazutoshi Takahashi et al.
CELL (2007)
Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity
Oscar M. Moradei et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
β-catenin overexpression in the mouse brain phenocopies lithium-sensitive Behaviors
Todd D. Gould et al.
NEUROPSYCHOPHARMACOLOGY (2007)
Lithium's effect in forced-swim test is blood level dependent but not dependent on weight loss
Yuly Bersudsky et al.
BEHAVIOURAL PHARMACOLOGY (2007)
The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics
Kelley C. O'Donnell et al.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2007)
Translation of research evidence from animals to humans
Daniel G. Hackam et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)
Lysine residues Lys-19 and Lys-49 of β-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation
Ira S. Winer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Regulatory cross-talk between lysine acetylation and ubiquitination: role in the control of protein stability
C Caron et al.
BIOESSAYS (2005)
Where is the evidence that animal research benefits humans?
P Pound et al.
BMJ-BRITISH MEDICAL JOURNAL (2004)
Glycogen synthase kinase-3β haploinsufficiency mimics the behavioral and molecular effects of lithium
WT O'Brien et al.
JOURNAL OF NEUROSCIENCE (2004)
PDZ domain proteins of synapses
EJ Kim et al.
NATURE REVIEWS NEUROSCIENCE (2004)
Chronic electroconvulsive seizure up-regulates β-catenin expression in rat hippocampus:: Role in adult neurogenesis
TM Madsen et al.
BIOLOGICAL PSYCHIATRY (2003)
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation
SJ Haggarty et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Acetylation of β-catenin by CREB-binding protein (CBP)
D Wolf et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Axin-mediated CKI phosphorylation of β-catenin at Ser 45:: a molecular switch for the Wnt pathway
S Amit et al.
GENES & DEVELOPMENT (2002)
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
CJ Phiel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)