期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ijms20102512
关键词
liver regeneration; liver resection; liver transplantation; portal hypertension; post-hepatectomy liver failure; small-for-size syndrome
资金
- FIS (Fondo de Investigacion Sanitaria) from the Carlos III Institute of Health (Ministry of Health and Consumption) [PI15/01092]
- European Regional Development Fund (FEDER)
Small-for-size livers arising in the context of liver resection and transplantation are vulnerable to the effects of increased portal flow in the immediate postoperative period. Increased portal flow is an essential stimulus for liver regeneration. If the rise in flow and stimulus for regeneration are excessive; however, liver failure and patient death may result. Somatostatin is an endogenous peptide hormone that may be administered exogenously to not only reduce portal blood flow but also offer direct protection to different cells in the liver. In this review article, we describe key changes that transpire in the liver following a relative size reduction occurring in the context of resection and transplantation and the largely beneficial effects that peri-operative somatostatin therapy may help achieve in this setting.
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