期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ijms20092342
关键词
Atg7; autophagy; lysosomes; placenta; preeclampsia; protein aggregation; p62; SQSTM1
资金
- AMED-CREST from the Japan Agency for Medical Research and Development [AMED 16gk0110018h0001]
- Kanzawa Medical Research Foundation
- Tamura Science and Technology Foundation
- Yamaguchi Endocrine Research Foundation
- First Bank of Toyama
- Toyama University Hospital [040200-59200003502]
- JSPS KAKENHI [JP17K11221, JP19K09750]
Autophagy is an evolutionarily conserved process in eukaryotes to maintain cellular homeostasis under environmental stress. Intracellular control is exerted to produce energy or maintain intracellular protein quality controls. Autophagy plays an important role in embryogenesis, implantation, and maintenance of pregnancy. This role includes supporting extravillous trophoblasts (EVTs) that invade the decidua (endometrium) until the first third of uterine myometrium and migrate along the lumina of spiral arterioles under hypoxic and low-nutrient conditions in early pregnancy. In addition, autophagy inhibition has been linked to poor placentationa feature of preeclamptic placentasin a placenta-specific autophagy knockout mouse model. Studies of autophagy in human placentas have revealed controversial results, especially with regard to preeclampsia and gestational diabetes mellitus (GDM). Without precise estimation of autophagy flux, wrong interpretation would lead to fixed tissues. This paper presents a review of the role of autophagy in pregnancy and elaborates on the interpretation of autophagy in human placental tissues.
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