期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/ijms20081811
关键词
skin resident immune cells; skin immune responses; inflammation; wound healing; impaired wound healing; scarring
资金
- Shriners Hospitals for Children
The skin is a complex organ that has devised numerous strategies, such as physical, chemical, and microbiological barriers, to protect the host from external insults. In addition, the skin contains an intricate network of immune cells resident to the tissue, crucial for host defense as well as tissue homeostasis. In the event of an insult, the skin-resident immune cells are crucial not only for prevention of infection but also for tissue reconstruction. Deregulation of immune responses often leads to impaired healing and poor tissue restoration and function. In this review, we will discuss the defensive components of the skin and focus on the function of skin-resident immune cells in homeostasis and their role in wound healing.
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