期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ijms20092067
关键词
alternative splicing; angiogenesis; VEGF; VEGFR; NRP; FGFR; vasohibin; HIF-1; angiopoietin
资金
- British Heart Foundation [PG/15/53/31371]
- Diabetes UK [17/0005668]
- BBSRC [BB/J007293/2, BB/P012035/1, BB/J007293/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J007293/2, BB/P012035/1, BB/J007293/1] Funding Source: researchfish
- British Heart Foundation [PG/15/53/31371] Funding Source: researchfish
Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an inhibitor of canonical isoform function, thereby adding an additional layer of regulation to important processes. Angiogenesis is an important process that is governed by alternative splicing mechanisms. This review focuses on the alternative spliced isoforms of key genes that are involved in the angiogenesis process; VEGF-A, VEGFR1, VEGFR2, NRP-1, FGFRs, Vasohibin-1, Vasohibin-2, HIF-1, Angiopoietin-1 and Angiopoietin-2.
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