期刊
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
卷 48, 期 3, 页码 849-860出版社
OXFORD UNIV PRESS
DOI: 10.1093/ije/dyz071
关键词
Sleep duration; Mendelian randomization; cognition; dementia
资金
- Indonesian Endowment Fund For Education [20160412045979]
- British Heart Foundation [FS/18/5/33319]
- National Institute for Health Research [RP-PG-0407-10314]
- Wellcome Trust [086091/Z/08/Z]
- Farr Institute of Health Informatics Research - Medical Research Council [MR/K006584/1]
- Arthritis Research UK
- Cancer Research UK
- Economic and Social Research Council
- Engineering and Physical Sciences Research Council
- National Institute of Health Research
- National Institute for Social Care and Health Research (Welsh Assembly Government)
- Chief Scientist Office (Scottish Government Health Directorates)
- Economic and Social Research Council and Medical Research Council [ES/J500185/1]
- UCL Springboard Population Science fellowship [105604/Z/14/Z]
- Wellcome Trust
- Medical Research Council, Department of Health of Scottish Government
- Northwest Regional Development Agency
- Welsh Assembly Government
- Wellcome Trust Medical Charity
- ESRC [ES/L007517/1] Funding Source: UKRI
- MRC [1940103] Funding Source: UKRI
- Wellcome Trust [105604/Z/14/Z] Funding Source: Wellcome Trust
Background: Short and long sleep duration have been linked with poorer cognitive outcomes, but it remains unclear whether these associations are causal. Methods: We conducted the first Mendelian randomization (MR) study with 77 single-nucleotide polymorphisms (SNPs) for sleep duration using individual-participant data from the UK Biobank cohort (N = 395 803) and summary statistics from the International Genomics of Alzheimer's Project (N cases/controls = 17 008/37 154) to investigate the potential impact of sleep duration on cognitive outcomes. Results: Linear MR suggested that each additional hour/day of sleep was associated with 1% [95% confidence interval (CI) = 0-2%; P = 0.008] slower reaction time and 3% more errors in visual-memory test (95% CI = 0-6%; P = 0.05). There was little evidence to support associations of increased sleep duration with decline in visual memory [odds ratio (OR) per additional hour/day of sleep = 1.10 (95% CI = 0.76-1.57); P = 0.62], decline in reaction time [OR = 1.28 (95% CI = 0.49-3.35); P = 0.61], all-cause dementia [OR = 1.19 (95% CI = 0.65-2.19); P = 0.57] or Alzheimer's disease risk [OR = 0.89 (95% CI = 0.67-1.18); P = 0.41]. Non-linear MR suggested that both short and long sleep duration were associated with poorer visual memory (P for non-linearity = 3.44e(-9)) and reaction time (P for non-linearity = 6.66e(-16)). Conclusions: Linear increase in sleep duration has a small negative effect on reaction time and visual memory, but the true association might be non-linear, with evidence of associations for both short and long sleep duration. These findings suggest that sleep duration may represent a potential causal pathway for cognition.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据