期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 128, 期 -, 页码 444-451出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2019.01.152
关键词
Arabinogalactan; Selenium nanoparticle; Anticancer
资金
- National Key R&D Program of China [2016YFD0600803]
- priority Academic Program Development of Jiangsu Higher Education Institution (PAPD)
- Doctorate Fellowship of Nanjing Forestry University
Selenium nanoparticles (SeNPs) were synthesized using arabinogalactans (LAG) as a formation scaffolding and particle stabilizer to investigate their anti-tumor properties. The formation, morphology, size, and in vitro biological activity of LAG-SeNPs were characterized by UV-vis, FT-IR, scanning electron microscopy (SEM), transmission electron microscopy (TEM), dynamic light scattering (DLS) and cell toxicity assays. SEM and TEM of LAG-SeNPs visualized the individual spherical nanoparticles, while the spectroscopic characterization revealed the modes of interaction which lead to the stable particle properties of the LAG-SeNPs. Cell toxicity assays indicated that the products had significant inhibitory effect on A549, HepG-2 and MCF-7 cells with a dose-dependent effect. The toxicity mechanisms of LAG-SeNPs were further investigated, and assay results revealed that LAG-SeNPs mainly induced cancer cellular apoptosis to promote atrophy and inhibit cell proliferation. The sum of these findings demonstrates the positive effects that a biomass-derived polysaccharide exert upon non-metal/metalloid-based nanoparticles and the ensuing material's viability as treatment against human cancers. (C) 2019 Elsevier B.V. All rights reserved.
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