期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 128, 期 -, 页码 499-508出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2019.01.145
关键词
Chitosan; CHCuO NPs; CHCu NPs
资金
- FONDECYT [3170272, 11160073]
- CIPA, CONICYT Regional, GORE BIO-BIO [R17A10003]
- Proyecto de Investigation enlace FONDECYT [300061]
Chitosan (CH) capped inorganic nanomaterials have been considered as significant antibacterial materials in the clinical field. This work shows the synthesis of two new different antibacterial composite films as a result of the incorporation of CH capped copper oxide (CHCuO) and copper (CHCu) nanoparticles (NPs). Here, CHCuO and CHCu NPs were achieved by a facile chemical reduction of Cu2+ ions using sodium hydroxide and ascorbic acid. TEM analysis revealed the morphology as rod-type nanoflakes for CHCuO and a spherical shape for CHCu NPs with similar to 7 +/- 2 nm size. Antimicrobial activity of the developed materials was studied by the inhibition zone method, against both gram-negative and gram-positive bacteria. The antimicrobial activity revealed that the CHCuO NPs and CHCuO-CH film showed a higher inhibition zone than the other nanomaterials. The results suggested that the synthesized materials can be used in wound dressing applications. (C) 2019 Elsevier B.V. All rights reserved.
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