期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 128, 期 -, 页码 665-672出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.01.186
关键词
Glycogen; Diabetes; Size-exclusion chromatography; Molecular structure
资金
- National Science Foundation of China [C130401 3151101138, 81803799, 81803230]
- 1000-Talents Program of the Chinese Foreign Experts Bureau
- Diabetes Australia [Y15G-GILR]
- NHMRC CJ Martin Fellowship [GNT1092451]
- Jiangsu Yangzhou Key Research and Development Program [SSF2018000008]
- Yangzhou University Young Scientist Innovation Fund
- Fundamental Research Funds for the Central Universities [2017KFYXJJ252, 2042018kf0143]
- Renmin Hospital of Wuhan University Guiding Fund [RMYD2018M57]
Glycogen is a complex branched glucose polymer. Liver glycogen in db/db mouse, a type-2 diabetic mouse model, has been found to be more molecularly fragile than in healthy mice. Size-exclusion chromatography was employed in this study to investigate the molecular structure of liver glycogen in two types of type 1 diabetic mouse models (NOD and C57BL/6J mice), sacrificed at various times throughout the diurnal cycle, and the fragility of liver glycogen after exposure to a hydrogen-bond disruptor were tested. Type 1 diabetic mice exhibit a similar glycogen fragility with that observed for db/db mice. This eliminates many of the potential causes for glycogen molecular fragility; the most likely explanation is that it is caused by high blood-glucose level and/or insulin deficiency, both phenotypes being common to both type 1 and type 2 diabetic mice. This result suggests ways towards new drug targets for the management of diabetes. (C) 2019 Elsevier B.V. All rights reserved.
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