期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 126, 期 -, 页码 786-795出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.12.079
关键词
TEMPO-oxidized cellulose nanofiber; Polyethylene glycol; Zinc oxide; Hemostatic; Antibacterial
资金
- Korea Forest Research Institute [FP0400-2016-01-2016]
- National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2015R1A6A03032522]
- Soonchunhyang University
- Korea Forest Service [FP0400-2016-01-2016] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Lethal bleeding due to street accidents, natural calamities, orthopedic/dental surgeries, organ transplantation and household injuries, is the leading cause of morbidity and mortality. In the current study, zinc oxide (ZnO) was incorporated in TEMPO-oxidized cellulose nanofiber (TOCN) and polyethylene glycol (PEG) polymer system for hemorrhage control by freeze drying method. SEM and XRD data showed the presence of ZnO in the porous structure. FT-IR analysis showed that, successful conjugation occurs among the TOCN and PEG. The results revealed that, the incorporation of ZnO and higher concentrations of PEG increased the degradability but decreased swelling of the scaffolds. The increase in PEG content and ZnO incorporation significantly decreased the bleeding time in rabbit ear arterial bleeding model. Further, the incorporation of ZnO enhanced the antibacterial property of TOCN-PEG. The results suggested that excellent hemostatic and mechanical properties of the TOCN-5% PEG-ZnO might contribute in controlling bleeding and reducing post traumatic dermal bacterial infection. (C) 2018 Published by Elsevier B.V.
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