期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 69, 期 -, 页码 382-388出版社
ELSEVIER
DOI: 10.1016/j.intimp.2019.01.049
关键词
Oridonin; Chondrocytes; IL-1 beta; NF-kappa B
资金
- research projects of the health and Health and Family Planning Commission of Heilongjiang Province [2017-065]
Osteoarthritis (OA), a progressive disease of the joints, affects millions of people worldwide. In the present study, we investigated the effects of oridonin, a diterpenoid isolated from Rabdosia rubescens, on IL-1 beta-induced inflammation using human osteoarthritis chondrocytes. The results showed that oridonin significantly suppressed IL-1 beta-induced MMP1, MMP3, and MMP13 production. IL-1 beta-induced NO and PGE(2) production, as well as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression were also attenuated by oridonin. Western blot analysis demonstrated IL-1 beta-induced NF-kappa B activation was reduced by oridonin. Furthermore, the expression of PPAR-gamma was increased by oridonin in a concentration-dependent manner. PPAR-gamma antagonist could reverse the anti-inflammatory activity of oridonin. The results suggested that oridonin could be a candidate agent for the treatment of OA.
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