期刊
INORGANIC CHEMISTRY
卷 58, 期 10, 页码 6593-6596出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.9b00734
关键词
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资金
- NSFC [21775062, 21505064]
- China Postdoctoral Science Foundation [2018M642606, 2017M622254]
- Project of Shandong Province Higher Educational Science and Technology Program [J16LC11]
- Natural Science Foundation of Shandong Province [ZR201709240033]
Here, DNA-functionalized nanoscale PCN-224 is established with the aptamer of A549 lung cancer cells. The aptamer was modified with carboxyl and fluorescein at the two terminals. When touching the A549 cells, DOX@PCN-224-DNA can trace tumor cells and present good targeting therapy by the combination of chemotherapy and photodynamic therapy. This facile aptamer functionalization of PCN-224 offers an opportunity to develop metal-organic framework-based target-directed therapy and biosensors.
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