期刊
INFLAMMATORY BOWEL DISEASES
卷 25, 期 12, 页码 1896-1905出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/ibd/izz059
关键词
inflammatory bowel disease; crohn's disease; ulcerative colitis; early biologic therapy; top-down therapy
资金
- NIDDK NIH HHS [K23 DK111995] Funding Source: Medline
The goals for treatment of inflammatory bowel diseases (IBDs) are changing from elimination of symptoms toward complete disease control-a process that demands both clinical and endoscopic remission. This new IBD treatment paradigm has been shifting from a conventional step-up approach toward a more top-down early intervention treatment strategy. Recent studies suggest that the use of biologic agents, specifically those targeting tumor necrosis factor alpha, earlier in the treatment course improves patient outcomes and can prevent progression to irreversible bowel damage. Although the strategy of early intervention has accumulating evidence in Crohn's disease, there is less evidence supporting its impact in ulcerative colitis.
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