期刊
IMMUNOLOGY LETTERS
卷 208, 期 -, 页码 39-43出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2019.02.007
关键词
Coronary artery disease; Atherosclerosis; NF-KB pathway; Gene polymorphisms; Genetic association
类别
资金
- Spanish Plan Nacional de I + D + I Ministerio de Economia y Competitividad
- European FEDER, grants ISCIII-Red de Investigation Renal-REDINREN [RD16/9/5, RD16/9/21]
The nuclear-factor kappa-beta (NF-KB) is a driver of inflammation, and plays an important role in the pathogenesis of atherosclerosis and coronary artery disease (CAD). Early-onset CAD is defined as a coronary ischaemic episode at an age <= 55 years, and in our population was strongly associated with male sex and smoking. Our aim was to determine whether common variants in three NF-KB genes were associated with early-onset CAD. We studied 609 patients with early-onset CAD and 423 healthy controls, all male. Allele and genotype frequencies for the NFKB1 rs28362491 (-94 deIATTG) and NFKBIA rs8904 were not significantly different between the two groups. For the NFKBIZ rs3217713, the deletion allele was significantly more frequent in the patients than in controls (0.27 vs. 0.22; p = 0.004). Deletion-carriers were more frequent in the patients (p < 0.001), with an OR = 1.48 (95%CI = 1.15-1.90). We performed a multiple logistic regression (linear generalized model) with smoking, hypercholesterolemia, type 2 diabetes, hypertension, and the rs3217713 deletion carriers remained significantly associated with early-onset CAD (p = 0.01). In our population, the NFKBIZ variant was an independent risk factor for developing early-onset CAD.
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