期刊
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
卷 39, 期 2, 页码 141-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2018.12.001
关键词
Asthma; Allergy; Rhinovirus; Prevention; Microbiome; Genetics
资金
- US National Heart, Lung, and Blood Institute [HL132523]
Inappropriate responses to respiratory viruses, especially rhinovirus, and early allergic sensitization are the strongest contributors to the inception and persistence of early onset asthma. The ORMDL3 asthma locus in chromosome 17q seems to exert its effects by increasing susceptibility to human rhinovirus in early life. Being raised on animal farms is highly protective against the development of asthma, and this protective effect is mediated by exposure to microbes. Two trials in high-risk young children, one to prevent wheezing lower respiratory tract illness using bacterial lyophilizates and another using anti-immunoglobulin E to prevent asthma progression, are already under way.
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