期刊
IMMUNOLOGICAL REVIEWS
卷 289, 期 1, 页码 84-100出版社
WILEY
DOI: 10.1111/imr.12758
关键词
CD4+T-cell priming; chemokine receptors; dendritic Cells; migration
类别
资金
- US National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases (NIAID) [1R01AI104725, 1R01AI116584]
- University of Alabama at Birmingham
Upon receiving cognate and co-stimulatory priming signals from antigen (Ag)-presenting dendritic cells (DCs) in secondary lymphoid tissues, naive CD4(+) T cells differentiate into distinct effector and memory populations. These alternate cell fate decisions, which ultimately control the T-cell functional attributes, are dictated by programming signals provided by Ag-bearing DCs and by other cells that are present in the microenvironment in which T-cell priming occurs. We know that DCs can be subdivided into multiple populations and that the various DC subsets exhibit differential capacities to initiate development of the different CD4(+) T-helper populations. What is less well understood is why different subanatomic regions of secondary lymphoid tissues are colonized by distinct populations of Ag-presenting DCs and how the location of these DCs influences the type of T-cell response that will be generated. Here we review how chemokine receptors and their ligands, which position allergen and nematode-activated DCs within different microdomains of secondary lymphoid tissues, contribute to the establishment of IL-4 committed follicular helper T and type 2 helper cell responses.
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