期刊
IMMUNOLOGICAL REVIEWS
卷 289, 期 1, 页码 62-83出版社
WILEY
DOI: 10.1111/imr.12746
关键词
chemokines; dendritic cells; lymph node organogenesis; lymphocyte migration; stromal cells
类别
资金
- German Research Foundation [SFB900-B1, SFB738-B3, FO334/5-1]
- Germany's Excellence Strategy - EXC 2155 RESIST [39087428]
- State of Lower Saxony
- ERC-Advanced Grant [AdG 322645]
Secondary lymphoid organs like lymph nodes (LNs) are the main inductive sites for adaptive immune responses. Lymphocytes are constantly entering LNs, scanning the environment for their cognate antigen and get replenished by incoming cells after a certain period of time. As only a minor percentage of lymphocytes recognizes cognate antigen, this mechanism of permanent recirculation ensures fast and effective immune responses when necessary. Thus, homing, positioning, and activation as well as egress require precise regulation within LNs. In this review we discuss the mediators, including chemokines, cytokines, growth factors, and others that are involved in the formation of the LN anlage and subsequent functional organization of LNs. We highlight very recent findings in the fields of LN development, steady-state migration in LNs, and the intranodal processes during an adaptive immune response.
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